Prediction of additional axillary metastasis of breast cancer with positive sentinel lymph nodes / 한국유방암학회지

PURPOSE: Axillary lymph node dissection in breast cancer patients with positive sentinel lymph node (SLN) is accepted as a routine procedure. In a significant proportion of women with breast cancer, the SLN is the sole site of regional metastasis. These patients would not be expected to benefit from complete lymph node dissection. The purpose of this study is to determine which factors are associated with additional positive lymph nodes in the axilla of patients who have positive sentinel lymph nodes. METHODS: Between September 2001 and May 2005, we examined 135 cases where the patients underwent a breast conserving operation and a SLN biopsy. There were 34 patients with positive SLN. Univariate analysis was used to identify the clinicopathologic features in the SLN positive patients that can predict metastasis in the nonsentinel lymph nodes (NSLNs). RESULTS: Fifteen patients (44.1%) had metastasis in the NSLNs. There were significant differences in the location of tumors (p=0.018), the nodal status of each patient (p=0.001) and c-erbB2 protein expression (p =0.017) in NSLN metastasis as determined by univariate analysis. CONCLUSION: The location of the breast cancer, nodal status and c-erbB2 expression are of predictive value for NSLN involvement. We suggest that a full axillary lymph node dissection may be considered as a sparing treatment in these situations.

Transferrin Receptors in Gliomas and its Relationship with Flow Cytometric Analysis

No abstract available.

Estrogen and Progesterone receptors in Meningioma

We studied the status of estrogen(ER) and progesterone(PR) receptors in meningiomas removed from 32 patients, using immunoperoxidase(IP) assays. PR were detected in 72% of the cases & ER were detected in 31%. The possible correlation between age, sex, histological type, ploidy pattern and proliferation index values with steroid receptor activity were discussed. The date suggest that the majority of meningiomas contain high affinity receptors for progesterone, that estrogen receptors are present in only a few meningiomas.

Flow Cytometric Analysis of DNA in Meningiomas

The Flow cytometric analysis of DNA in tumors have been reported to reflect the cellular activities and proliferative rates. Currently, it has been used to predict the prognosis and responsiveness of tumors to various modality of therapy. The author analyzed thirty seven meningiomas(7 syncytial, 9 transitional, 6 fibroblastic, 9 angioblastic, 6 atypical) using paraffinembeddede tissues. The ploidy pattern and relative value(%) in the GO/GI, S, and G2/M phases were calculated for each specimen. In our series, All were diploid types except 6 meningiomas(2 syncytial, 2 angioblastic, 2 atypical). Diploidy with weak tetraploidy(upto 10%) was found in 8 cases(40% of atypical, 33% of fibrobiastic and transitional) but not in syncytial meningioma. Diploidy with strong teraploigy(10-25%) was found in 1 transitional, 1 angioblastic meningioma. There was wide variation in 4C values even in the same subgroups of meningiomas. The distribution of P. I values is even and lower especially in fibroblastic meningiomas. On the contrary, the distribution of P. I values is relatively uneven and highly variable in other types of meningiomas & even in the same subgroups of meningiomas except fibroblastic meningioma. The prediction of recurrences in operated cases remained further investigation due to lack of long-term follow-up.